Selected Publications

  1. Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and Zhang, J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 independently of its ubiquitin ligase activity. Cell Reports 1:472, 2012
  2. Qiao, G., Zhao, Y., Li, Z., Tang, P.Q., Yang, T., and Zhang, J. T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines the fate of inducible regulatory T cells. J. Immunol.; 191:632, 2013.
  3. Qiao, G., Ying, H., Liang, Y., Guo, H., Zhao, Y., Li, Z., Chen, B., Zhu, X., Solway, J., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and Zhang, J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports 6:709, 2014
  4. Zhao, Y., Guo, H., Qiao, G., Zucker, M., Langdon, W.Y., and Zhang, J. E3 ubiquitin ligase Cbl-b regulates thymic-derived CD4+CD25+ regulatory T cell development by targeting Foxp3 for ubiquitination. J. Immunol. 194:1639, 2015
  5. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and Zhang, J.  Targeting CBLB as a potential therapeutic approach for disseminated candidiasis.  Nat. Med. 22:906, 2016
  6. Tang, J., Lin, G., Langdon, W.Y., Tang, L., and Zhang, J. Regulation of C-type lectin receptor-mediated anti-fungal immunity. Front. Immunol. 9:123, 2018
  7. Ouyang, S., Zeng, Z., Guo, H., Tang, N., Tang, R., Yin, W., Wang, A., Tang, H., Zhou, J., Xie, H., Langdon, W.Y., Yang, H., and Zhang, J.  Akt-1 and Akt-2 differentially the development of experimental autoimmune encephalomyelitis by controlling proliferation of thymus-derived regulatory T cells. J. Immunol.  202:1441, 2019
  8. Tang, J., Tu, S., Lin, G., Guo, H., Yan, C., Liu, Q., Huang, L., Tang, N., Xiao, Y., Pope, R.M., Rajaram, M.V.S., Amer, A.O., Ahmer, B.M., Gunn, J.S., Wozniak, D.J., Tao, L., Vincenzo, C., Zhang, L., Langdon, W.Y., Torrelles, J.B., Lipkowitz, S., and Zhang, G. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.  J. Exp. Med. 217(4):e20182091, 2020
  9. Nuro-Gyna, P., Tang, Na., Guo, H., Yan, C., and Zhang, J.  E3 ubiquitin ligase Nedd4 is required for antifungal innate immunity.  J. Immunol.  207:868, 2021 (featured in August 1’s issue by Top Reads)
  10. Tang, J., Xiao, Y., Lin, G., Guo, H., Deng, H-X., Tu, S., Langdon, W.Y., Yang, H., Tao, L., Li, Y., Pope, R.M., Gupta, T., and Zhang, J. Tyrosine phosphorylation of NLRP3 by Src family protein tyrosine kinase Lyn suppresses NLRP3 inflammasome activation. Sci Signal 14:eabe3410, 2021