1160 Medical Laboratories
Welcome to the Laboratory of Jian Zhang, MD in the Department of Pathology at the University of Iowa.
Our laboratory studies molecular mechanisms of T cell activation and differentiation, and innate immune responses regulated by E3 ubiquitin ligases Cbl-b and Nedd4. We have identified several novel proteins targeted by Cbl-b in T cells and innate immune cells, and are investigating 1) whether and how Cbl-b regulates the development of T follicular helper cells (TFH), CD8+ cytotoxic T cells (Tc) and innate lymphoid cells (ILCs); 2) how Cbl-b regulates the innate immune cells sensing Candida albicans and other fungi; and 3) how Cbl-b controls sepsis and septic shock. In addition, we have also identified several novel substrates of Nedd4 in T cells and innate immune cells, are studying Nedd4 in T helper cell development and autoimmune/inflammatory diseases as well as in fungal infections and endotoxemia. Further understanding of these E3 ubiquitin ligases in innate and adaptive immunity will lead to the development of therapeutic invention for human diseases such as multiple sclerosis, allergic asthma, inflammatory bowel disease, and infectious diseases.
Front row from left to right: Hui Guo, Huilan Zeng, Na Tang, Sha Tu, Patrick Nuro-Gyina
Back row from left to right: Jian Zhang, Yizhi Xiao, Monisha Mittal, Yilei Ma, Chengkai Yan